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Early intervention service programs endeavor to reduce symptoms of psychosis, improve functional outcomes, and decrease long-term disability.However, to date there has been only 1 meta-analysis covering only 4 randomized trials comparing early intervention services with treatment as usual in early-phase psychosis.First Episode Psychosis programs serve people 15 to 40 with early signs of psychosis.

In Minnesota, there are currently two Twin Cities pilot sites: Over the next two years, these sites will recruit and work with individuals and families experiencing their first episode of psychosis.In 2008, the National Institute of Mental Health launched the Recovery After an Initial Schizophrenia Episode (RAISE) study.The risk ratio (RR) for all-cause treatment discontinuation for early intervention services vs treatment as usual was 0.70 (P The modest number of trials and patients included and the heterogeneity usually inherent to such analyses were limits to the current review.The investigators argued that given the high degree of personal distress and societal costs, the superior benefit provided by early intervention services could be cost-effective, and they call for widespread implementation and funding of early intervention services in the United States and globally. Comparison of early intervention services vs treatment as usual for early-phase psychosis: a systematic review, meta-analysis, and meta-regression [published online May 2, 2018]. Yet, studies have shown that it is common for a person to have psychotic symptoms for more than a year before receiving treatment.

Coordinated Specialty Care is a recovery-oriented treatment program for people with first episode psychosis.

Median recovery is only 13.5%, and individuals with schizophrenia die on average 15 to 20 years earlier than the general population.

Patients with early-phase disease generally respond better to treatment, and there has been a focus on early identification and optimized intervention.

The investigators undertook the current meta-analysis to include more recently published trials. Correl, MD, of the Department of Psychiatry at The Zucker Hillside Hospital, Northwell Health in Glen Oaks, New York, and colleagues performed a systematic literature search of Pub Med, Psyc INFO, EMBASE, and Clinical through June 6, 2017 and identified 10 randomized clinical trials comparing early intervention services with treatment as usual in first-episode psychosis or early-phase schizophrenia spectrum disorders.

This systematic review and meta-analysis was conducted according to PRISMA guidelines.

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